Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 10/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 8/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL886357 | 0.94 | KCNA5 (0.54) | KCNA5KCNH2S1PR1MEN1KMT2A | |
| SCHEMBL884729 | 0.93 | KCNA5 (0.43) | KCNA5KCNH2S1PR1 | |
| SCHEMBL2062951 | 0.88 | KCNA5 (0.43) | KCNA5KCNH2S1PR1MEN1KMT2A | |
| SCHEMBL885978 | 0.88 | KCNA5 (0.42) | KCNA5KCNH2 | |
| SCHEMBL885665 | 0.88 | KCNA5 (0.42) | KCNA5KCNH2 | |
| SCHEMBL884813 | 0.87 | KCNA5 (0.43) | KCNA5KCNH2MEN1KMT2A | |
| SCHEMBL885452 | 0.86 | RPS6KB1 (0.38) | KCNA5KCNH2S1PR1 | |
| SCHEMBL886322 | 0.86 | KCNA5 (0.39) | KCNA5KCNH2S1PR1 | |
| SCHEMBL2063303 | 0.85 | KCNA5 (0.45) | KCNA5KCNH2S1PR1 | |
| SCHEMBL2062950 | 0.85 | KCNA5 (0.47) | KCNA5KCNH2S1PR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090233897-A1 | Potassium Channel Inhibitors | MERCK SHARP & DOHME CORP. | 2009-09-17 | — | — | US | claimed |
| US-8148535-B2 | Potassium channel inhibitors | MERCK SHARP & DOHME CORP. (US) | 2012-04-03 | — | — | US | disclosed |
| US-20090233897-A1 | Potassium Channel Inhibitors | MERCK SHARP & DOHME CORP. | 2009-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233897-A1 | Potassium Channel Inhibitors | KCNJ2, KCNQ2, KCNH2 | KCNA5 11/4885KCNH2 3/4885S1PR1 1283/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.