SCHEMBL20627554

SCHEMBL20627554

Nc1ncc(-c2ccc(-c3ccccc3C(=O)N3CCCCC3)cc2F)cn1

nearest known ligand 0.81

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
FEN1 P39748 20/20 0.81
ALOX5AP P20292 19/20 0.81

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15917047 0.89 ALOX5AP (1.00) FEN1ALOX5AP
SCHEMBL15917360 0.89 FEN1 (0.76) FEN1ALOX5AP
SCHEMBL15917361 0.89 FEN1 (0.76) FEN1ALOX5AP
SCHEMBL20627518 0.88 FEN1 (0.75) FEN1ALOX5AP
SCHEMBL15916301 0.87 ALOX5AP (0.77) FEN1ALOX5AP
SCHEMBL15924792 0.87 ALOX5AP (0.77) FEN1ALOX5AP
SCHEMBL15916983 0.87 ALOX5AP (0.77) FEN1ALOX5AP
SCHEMBL21088766 0.86 ALOX5AP (0.70) FEN1ALOX5AP
SCHEMBL15917231 0.86 FEN1 (0.74) FEN1ALOX5AP
SCHEMBL20627073 0.85 FEN1 (0.80) FEN1ALOX5AP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3495359-A1 FLAP MODULATORS Janssen Pharmaceutica NV (BE) 2019-06-12 EP disclosed
EP-3070085-B1 FLAP MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2019-01-09 EP disclosed