Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 2/20 | 0.35 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 4/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CTSB | P07858 | 1/20 | 0.31 |
| ▸ | GALR3 | O60755 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.30 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.30 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.30 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.30 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13458553 | 1.00 | MEN1 (0.37) | MEN1KMT2APIM1PIM3PIM2 | |
| SCHEMBL2832661 | 0.85 | PIM1 (0.44) | MEN1KMT2APIM1PIM3PIM2 | |
| SCHEMBL2832662 | 0.85 | PIM1 (0.44) | MEN1KMT2APIM1PIM3PIM2 | |
| SCHEMBL1711410 | 0.85 | PIM1 (0.44) | MEN1KMT2APIM1PIM3PIM2 | |
| SCHEMBL18700540 | 0.85 | PIM1 (0.44) | MEN1KMT2APIM1PIM3PIM2 | |
| SCHEMBL18427343 | 0.82 | MEN1 (0.35) | MEN1KMT2AMAPTALDH1A1HTT | |
| SCHEMBL13707746 | 0.80 | MEN1 (0.37) | MEN1KMT2AMAPTALDH1A1HTT | |
| SCHEMBL13458184 | 0.79 | MEN1 (0.33) | MEN1KMT2APIM1PIM3PIM2 | |
| SCHEMBL15604496 | 0.79 | MEN1 (0.33) | MEN1KMT2APIM1PIM3PIM2 | |
| SCHEMBL12697033 | 0.78 | KMT2A (0.36) | MEN1KMT2APIM1PIM3PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2861585-B1 | NOVEL RING-SUBSTITUTED N-PYRIDINYL AMIDES AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2019-01-09 | — | — | EP | disclosed |