Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K11 | Q16584 | 6/20 | 0.53 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | SGK1 | O00141 | 3/20 | 0.39 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | CFTR | P13569 | 1/20 | 0.39 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CLK1 | P49759 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL723236 | 0.83 | MAP3K11 (0.77) | MAP3K11TNIKIGF1RSGK1CAMKK2 | |
| SCHEMBL720872 | 0.77 | MAP3K11 (0.78) | MAP3K11TNIKSGK1CAMKK2CRBN | |
| SCHEMBL18129614 | 0.73 | MAP3K11 (0.50) | MAP3K11TNIKSGK1CAMKK2KIT | |
| SCHEMBL721847 | 0.70 | MAP3K11 (1.00) | MAP3K11TNIKIGF1RSGK1CAMKK2 | |
| SCHEMBL18129789 | 0.70 | SGK1 (0.53) | MAP3K11SGK1CAMKK2 | |
| SCHEMBL18129726 | 0.69 | SGK1 (0.55) | MAP3K11SGK1CAMKK2 | |
| SCHEMBL7508493 | 0.69 | MAP3K11 (0.83) | MAP3K11TNIKSGK1CAMKK2NTRK1 | |
| SCHEMBL721581 | 0.68 | MAP3K11 (0.85) | MAP3K11TNIKSGK1CAMKK2NTRK1 | |
| SCHEMBL8252454 | 0.68 | KMT2A (0.72) | HDAC4CRBNMAPK1 | |
| SCHEMBL31694698 | 0.67 | MAP4K1 (0.54) | MAP3K11SGK1MAP4K1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2925319-B1 | MIXED LINEAGE KINASE INHIBITORS FOR HIV/AIDS THERAPIES | UNIV ROCHESTER (US) | 2019-01-09 | — | — | EP | disclosed |