Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 20/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 12/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 11/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 10/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.46 |
| ▸ | NCOR2 | Q9Y618 | 4/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20605239 | 0.86 | HDAC6 (0.70) | HDAC6HDAC8HDAC2HDAC1HDAC10 | |
| SCHEMBL20635512 | 0.84 | HDAC6 (0.53) | HDAC6HDAC8HDAC2HDAC1HDAC10 | |
| SCHEMBL20605229 | 0.83 | HDAC6 (0.56) | HDAC6HDAC8HDAC2HDAC1HDAC10 | |
| SCHEMBL19138896 | 0.79 | HDAC6 (0.71) | HDAC6HDAC8HDAC2HDAC1HDAC10 | |
| SCHEMBL19161577 | 0.79 | HDAC6 (0.71) | HDAC6HDAC8HDAC2HDAC1HDAC10 | |
| SCHEMBL17520537 | 0.79 | HDAC6 (0.70) | HDAC6HDAC8HDAC2HDAC1HDAC10 | |
| SCHEMBL20605226 | 0.79 | HDAC6 (0.55) | HDAC6HDAC8HDAC2HDAC1HDAC10 | |
| SCHEMBL17500242 | 0.78 | HDAC6 (0.69) | HDAC6HDAC8HDAC2HDAC1HDAC10 | |
| SCHEMBL17520432 | 0.78 | HDAC6 (0.72) | HDAC6HDAC8HDAC2HDAC1HDAC10 | |
| SCHEMBL19138907 | 0.77 | HDAC6 (0.73) | HDAC6HDAC8HDAC2HDAC1HDAC10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019007836-A1 | NOVEL HDAC6 INHIBITORS, WITH IMPROVED SOLUBILITY AND THEIR USES | UNIVERSITÄT REGENSBURG (DE) | 2019-01-10 | — | — | WO | disclosed |