Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 18/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 11/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 10/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.47 |
| ▸ | NCOR2 | Q9Y618 | 3/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20605315 | 0.85 | HDAC6 (0.62) | HDAC6HDAC8HDAC2HDAC1HDAC10 | |
| SCHEMBL17500228 | 0.79 | HDAC6 (0.64) | HDAC6HDAC8HDAC2HDAC1HDAC10 | |
| SCHEMBL20605283 | 0.77 | HDAC6 (0.81) | HDAC6HDAC8HDAC2HDAC1HDAC10 | |
| SCHEMBL19138956 | 0.76 | HDAC6 (0.82) | HDAC6HDAC8HDAC2HDAC1HDAC10 | |
| SCHEMBL19161261 | 0.76 | HDAC6 (0.82) | HDAC6HDAC8HDAC2HDAC1HDAC10 | |
| SCHEMBL20605285 | 0.75 | HDAC6 (0.77) | HDAC6HDAC8HDAC2HDAC1HDAC10 | |
| SCHEMBL19169003 | 0.75 | HDAC6 (0.69) | HDAC6HDAC8HDAC2HDAC1HDAC10 | |
| SCHEMBL20629250 | 0.73 | HDAC6 (0.57) | HDAC6HDAC8HDAC2HDAC1HDAC10 | |
| SCHEMBL17520538 | 0.73 | HDAC6 (0.81) | HDAC6HDAC8HDAC2HDAC1HDAC10 | |
| SCHEMBL17500314 | 0.72 | HDAC6 (0.81) | HDAC6HDAC8HDAC2HDAC1HDAC10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019007836-A1 | NOVEL HDAC6 INHIBITORS, WITH IMPROVED SOLUBILITY AND THEIR USES | UNIVERSITÄT REGENSBURG (DE) | 2019-01-10 | — | — | WO | disclosed |