Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K11 | Q16584 | 16/20 | 0.53 |
| ▸ | IKBKB | O14920 | 2/20 | 0.50 |
| ▸ | CHUK | O15111 | 2/20 | 0.50 |
| ▸ | ABL1 | P00519 | 2/20 | 0.50 |
| ▸ | INSR | P06213 | 2/20 | 0.50 |
| ▸ | CDK2 | P24941 | 2/20 | 0.50 |
| ▸ | FLT3 | P36888 | 2/20 | 0.50 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.50 |
| ▸ | SGK1 | O00141 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.50 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | CDK1 | P06493 | 1/20 | 0.50 |
| ▸ | IGF1R | P08069 | 1/20 | 0.50 |
| ▸ | MET | P08581 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | SRC | P12931 | 1/20 | 0.50 |
| ▸ | FLT1 | P17948 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20634830 | 0.89 | MAP3K11 (0.67) | MAP3K11IKBKBCHUKABL1INSR | |
| SCHEMBL25153339 | 0.86 | MAP3K11 (0.56) | MAP3K11IKBKBCHUKABL1INSR | |
| SCHEMBL25153340 | 0.85 | MAP3K11 (0.53) | MAP3K11IKBKBCHUKABL1INSR | |
| SCHEMBL25153320 | 0.83 | MAP3K11 (0.55) | MAP3K11IKBKBCHUKABL1INSR | |
| SCHEMBL12065811 | 0.82 | MAP3K11 (0.49) | MAP3K11IKBKBCHUKABL1INSR | |
| SCHEMBL20634857 | 0.82 | MAP3K11 (0.49) | MAP3K11IKBKBCHUKABL1INSR | |
| SCHEMBL20634236 | 0.79 | MAP3K11 (0.58) | MAP3K11IKBKBCHUKABL1INSR | |
| SCHEMBL12066036 | 0.78 | MAP3K11 (0.70) | MAP3K11IKBKBCHUKABL1INSR | |
| SCHEMBL25153604 | 0.74 | DYRK1A (0.40) | MAP3K11IKBKBCHUKABL1INSR | |
| SCHEMBL27923804 | 0.71 | MAP3K11 (0.73) | MAP3K11IKBKBCHUKABL1INSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2925319-B1 | MIXED LINEAGE KINASE INHIBITORS FOR HIV/AIDS THERAPIES | UNIV ROCHESTER (US) | 2019-01-09 | — | — | EP | disclosed |