SCHEMBL206367

SCHEMBL206367

O=C(Nc1cccc2c1CC(O)CC2)Nc1cccc(-c2ccccc2)c1C(F)(F)F

nearest known ligand 0.58

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TRPV1 Q8NER1 20/20 0.58
OPRM1 P35372 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4336802 0.82 TRPV1 (0.70) TRPV1OPRM1
SCHEMBL207450 0.81 TRPV1 (0.69) TRPV1OPRM1
SCHEMBL4336612 0.80 TRPV1 (0.64) TRPV1
SCHEMBL13613690 0.79 TRPV1 (0.59) TRPV1
SCHEMBL4332079 0.78 TRPV1 (0.71) TRPV1OPRM1
SCHEMBL2734361 0.78 TRPV1 (0.67) TRPV1OPRM1
SCHEMBL208537 0.77 TRPV1 (0.66) TRPV1OPRM1
SCHEMBL4333852 0.77 TRPV1 (0.71) TRPV1OPRM1
SCHEMBL13613696 0.76 TRPV1 (0.59) TRPV1
SCHEMBL13613693 0.76 TRPV1 (0.59) TRPV1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8088826-B2 2-Hydroxy-1,2,3,4-tetrahydronaphthalenes substituted in the 8-position with a biphenylcarbonylamino-, biphenylcarbonylaminoalkyl-, biphenylaminocarbonylamino-, or biphenylaminocarbonylaminoalkyl-groups; vanilloid receptor antagonists; analgesics antiinflammatory agent; urogenital disorders XENTION LIMITED (GB) 2012-01-03 US claimed