Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 20/20 | 0.72 |
| ▸ | S1PR3 | Q99500 | 17/20 | 0.72 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2065306 | 1.00 | S1PR1 (0.72) | S1PR1S1PR3S1PR5 | |
| SCHEMBL883951 | 1.00 | S1PR1 (0.72) | S1PR1S1PR3S1PR5 | |
| SCHEMBL884139 | 0.89 | S1PR1 (0.81) | S1PR1S1PR3S1PR5 | |
| SCHEMBL884141 | 0.89 | S1PR1 (0.81) | S1PR1S1PR3S1PR5 | |
| SCHEMBL884056 | 0.88 | S1PR1 (0.92) | S1PR1S1PR3S1PR5 | |
| SCHEMBL2065169 | 0.88 | S1PR1 (0.92) | S1PR1S1PR3S1PR5 | |
| SCHEMBL2065479 | 0.88 | S1PR1 (0.92) | S1PR1S1PR3S1PR5 | |
| SCHEMBL2064894 | 0.84 | S1PR1 (0.55) | S1PR1S1PR3S1PR5 | |
| SCHEMBL884103 | 0.84 | S1PR1 (1.00) | S1PR1S1PR3S1PR5 | |
| SCHEMBL884104 | 0.84 | S1PR1 (1.00) | S1PR1S1PR3S1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222667-B1 | NOVEL THIOPHENE DERIVATIVES AS AGONISTS OF S1P1/EDG1 | ACTELION PHARMACEUTICALS LTD (CH) | 2013-02-20 | — | — | EP | disclosed |
| US-8148410-B2 | Thiophene derivatives as agonists of S1P1/EDG1 | ACTELION PHARMACEUTICALS LTD. (CH) | 2012-04-03 | — | — | US | disclosed |
| EP-2222667-A2 | NOVEL THIOPHENE DERIVATIVES AS AGONISTS OF S1P1/EDG1 | Actelion Pharmaceuticals Ltd. (CH) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009074950-A2 | THIOPHENE DERIVATIVES AS AGONISTS OF S1P1/EDG1 | ACTELION PHARMACEUTICALS LTD (CH) | 2009-06-18 | — | — | WO | disclosed |