Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.59 |
| ▸ | ERN1 | O75460 | 3/20 | 0.55 |
| ▸ | ABL1 | P00519 | 2/20 | 0.53 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.53 |
| ▸ | BCR | P11274 | 2/20 | 0.53 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP4B1 | P13584 | 1/20 | 0.50 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.50 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.50 |
| ▸ | CYP2A7 | P20853 | 1/20 | 0.50 |
| ▸ | CYP3A7 | P24462 | 1/20 | 0.50 |
| ▸ | CYP2F1 | P24903 | 1/20 | 0.50 |
| ▸ | CYP2C18 | P33260 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1690557 | 0.86 | PARP1 (0.80) | PARP1ERN1PLAUPLATPLG | |
| SCHEMBL24163686 | 0.85 | PARP1 (0.49) | PARP1ERN1PARP10PARP2 | |
| SCHEMBL16116617 | 0.84 | PARP1 (0.62) | PARP1ERN1ABL1ABCB1BCR | |
| SCHEMBL3720494 | 0.81 | PARP1 (0.67) | PARP1ABL1ABCB1BCRCYP1A2 | |
| SCHEMBL1147444 | 0.79 | PARP1 (0.77) | PARP1ERN1CYP3A4CYP2C9HSD17B2 | |
| SCHEMBL3662153 | 0.78 | MKNK1 (0.72) | PARP1ERN1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL3659867 | 0.78 | CYP11B1 (0.68) | PARP1ERN1CYP1A2CYP3A4PLAU | |
| SCHEMBL17175623 | 0.77 | PARP1 (0.56) | PARP1ERN1CHEK2ESR2 | |
| SCHEMBL2431097 | 0.77 | PARP1 (0.64) | PARP1ERN1CYP3A4CYP2C19 | |
| SCHEMBL31422694 | 0.77 | PARP1 (0.64) | PARP1ERN1CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3988540-A1 | INHIBITORS OF FATTY ACID AMIDE HYDROLASE (FAAH) ENZYME WITH IMPROVED ORAL BIOAVAILABILITY AND THEIR USE AS MEDICAMENTS | The Regents of the University of California (US) | 2022-04-27 | — | — | EP | disclosed |
| EP-3129354-B1 | INHIBITORS OF FATTY ACID AMIDE HYDROLASE (FAAH) ENZYME WITH IMPROVED ORAL BIOAVAILABILITY AND THEIR USE AS MEDICAMENTS | UNIV CALIFORNIA (US) | 2022-01-05 | — | — | EP | disclosed |
| EP-2744778-B1 | META-SUBSTITUTED BIPHENYL PERIPHERALLY RESTRICTED FAAH INHIBITORS | UNIV CALIFORNIA (US) | 2019-01-16 | — | — | EP | disclosed |