Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN10A | Q9Y5Y9 | 6/20 | 0.48 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.47 |
| ▸ | ABL1 | P00519 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20639029 | 0.93 | SCN10A (0.53) | SCN10ASCN8AABL1KDM4EMAPT | |
| SCHEMBL20652810 | 0.93 | SCN10A (0.47) | SCN10ASCN8AABL1KMT2AATM | |
| SCHEMBL20652578 | 0.84 | SCN10A (0.51) | SCN10ASCN8ASMN1; SMN2KMT2A | |
| SCHEMBL20638807 | 0.82 | SCN10A (0.53) | SCN10AABL1KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL22209164 | 0.81 | SMN1; SMN2 (0.48) | SCN10ASCN8AABL1KDM4EMAPT | |
| SCHEMBL20638966 | 0.80 | SMN1; SMN2 (0.48) | SCN10ASCN8AKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL20652572 | 0.79 | SCN10A (0.49) | SCN10ASCN8AABL1 | |
| SCHEMBL20638987 | 0.79 | SCN10A (0.55) | SCN10ASCN8A | |
| SCHEMBL20639032 | 0.79 | SMN1; SMN2 (0.47) | SCN10ASCN8AKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL20639312 | 0.79 | SCN10A (0.57) | SCN10ASCN8A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019014352-A1 | CARBOXAMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2019-01-17 | — | — | WO | disclosed |