Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 11/20 | 0.60 |
| ▸ | HTR2C | P28335 | 9/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | ALPI | P09923 | 1/20 | 0.42 |
| ▸ | ALPG | P10696 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5063296 | 0.81 | HTR2A (0.79) | HTR2AHTR2CKMT2A | |
| SCHEMBL2064660 | 0.81 | HTR2A (0.74) | HTR2AHTR2C | |
| SCHEMBL884357 | 0.81 | HTR2A (0.88) | HTR2AHTR2C | |
| SCHEMBL884030 | 0.78 | HTR2A (0.70) | HTR2AHTR2C | |
| SCHEMBL2063845 | 0.78 | KDM6B (0.55) | HTR2AHTR2CALDH1A1KDM4EHSD17B10 | |
| SCHEMBL2064457 | 0.77 | HTR2A (0.82) | HTR2AHTR2C | |
| SCHEMBL1165507 | 0.77 | HTR2A (0.77) | HTR2AHTR2C | |
| SCHEMBL884788 | 0.76 | HTR2A (1.00) | HTR2AHTR2C | |
| SCHEMBL29572894 | 0.75 | HTR2A (0.78) | HTR2AHTR2CKDM4ESMN1; SMN2HTT | |
| SCHEMBL1166745 | 0.75 | HTR2A (0.78) | HTR2AHTR2CKDM4ESMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8148417-B2 | Primary amines and derivatives thereof as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto | ARENA PHARMACEUTICALS, INC. (US) | 2012-04-03 | — | — | US | disclosed |