Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTP4A3 | O75365 | 11/20 | 1.00 |
| ▸ | PTPN1 | P18031 | 5/20 | 0.62 |
| ▸ | GSK3B | P49841 | 1/20 | 0.57 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.53 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.51 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.51 |
| ▸ | PPARG | P37231 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10090207 | 1.00 | PTP4A3 (1.00) | PTP4A3PTPN1GSK3BADAMTS5PTPN2 | |
| SCHEMBL2066174 | 1.00 | PTP4A3 (1.00) | PTP4A3PTPN1GSK3BADAMTS5PTPN2 | |
| SCHEMBL885422 | 0.91 | PTP4A3 (0.83) | PTP4A3PTPN1GSK3BADAMTS5 | |
| SCHEMBL2065839 | 0.91 | PTP4A3 (0.83) | PTP4A3PTPN1GSK3BADAMTS5 | |
| SCHEMBL2066164 | 0.90 | PTP4A3 (0.81) | PTP4A3PTPN1GSK3BADAMTS5 | |
| SCHEMBL10090222 | 0.90 | PTP4A3 (0.81) | PTP4A3PTPN1GSK3BADAMTS5PTPN2 | |
| SCHEMBL2066162 | 0.90 | PTP4A3 (0.81) | PTP4A3PTPN1GSK3BADAMTS5 | |
| SCHEMBL2065640 | 0.90 | PTP4A3 (1.00) | PTP4A3PTPN1GSK3BADAMTS5 | |
| SCHEMBL2066459 | 0.90 | PTP4A3 (0.81) | PTP4A3PTPN1GSK3BADAMTS5PTPN2 | |
| SCHEMBL2066462 | 0.90 | PTP4A3 (0.81) | PTP4A3PTPN1GSK3BADAMTS5PTPN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8148541-B2 | Rhodanine derivatives, a process for the preparation thereof and pharmaceutical composition containing the same | KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) | 2012-04-03 | — | — | US | claimed |
| US-20090042872-A1 | Rhodanine Derivatives, a Process for the Preparation Thereof and Pharmaceutical Composition Containing the Same | KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) | 2009-02-12 | — | — | US | claimed |
| EP-3310355-B1 | PTP4A3 INHIBITOR FOR THE TREATMENT OF CANCER | UNIV VIRGINIA PATENT FOUNDATION (US) | 2020-11-11 | — | — | EP | disclosed |
| US-10308663-B2 | Inhibitors of PTP4A3 for the treatment of cancer | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2019-06-04 | — | — | US | disclosed |
| US-20180170946-A1 | INHIBITORS OF PTP4A3 FOR THE TREATMENT OF CANCER | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-06-21 | — | — | US | disclosed |
| US-20180170946-A1 | INHIBITORS OF PTP4A3 FOR THE TREATMENT OF CANCER | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-06-21 | — | — | US | disclosed |
| WO-2016205534-A1 | INHIBITORS OF PTP4A3 FOR THE TREATMENT OF CANCER | LAZO JOHN S (US) | 2016-12-22 | — | — | WO | disclosed |
| US-8148541-B2 | Rhodanine derivatives, a process for the preparation thereof and pharmaceutical composition containing the same | KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) | 2012-04-03 | — | — | US | disclosed |
| US-20090042872-A1 | Rhodanine Derivatives, a Process for the Preparation Thereof and Pharmaceutical Composition Containing the Same | KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) | 2009-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090042872-A1 | Rhodanine Derivatives, a Process for the Preparation Thereof and Pharmaceutical Composition Containing the Same | PTPRR, PTPRG, PTPRS | PTP4A3 28/4885PTPN1 26/4885GSK3B 390/4885 |
| US-10308663-B2 | Inhibitors of PTP4A3 for the treatment of cancer | PTP4A3, PTPRCAP, PTP4A1 | PTP4A3 1/4885PTPN1 24/4885GSK3B 325/4885 |
| US-20180170946-A1 | INHIBITORS OF PTP4A3 FOR THE TREATMENT OF CANCER | PTP4A3, PTPRCAP, PTP4A1 | PTP4A3 1/4885PTPN1 24/4885GSK3B 325/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.