Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 12/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 12/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | TKT | P29401 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16606310 | 0.83 | CYP1A2 (0.43) | CYP2C9NAMPTCYP11B1CYP11B2CYP3A4 | |
| SCHEMBL10061636 | 0.81 | CYP11B1 (0.43) | CYP2C9NAMPTCYP11B1CYP11B2CYP3A4 | |
| SCHEMBL23623785 | 0.79 | CYP2C9 (0.39) | CYP2C9NAMPTCYP11B1CYP11B2CYP3A4 | |
| SCHEMBL2260514 | 0.78 | KDR (0.38) | CYP2C9NAMPTCYP11B1CYP11B2CYP3A4 | |
| SCHEMBL20069151 | 0.76 | KCNH2 (0.46) | CYP2C9NAMPTCYP11B1CYP11B2CYP3A4 | |
| SCHEMBL17886903 | 0.76 | CYP11B1 (0.40) | CYP2C9NAMPTCYP11B1CYP11B2CYP3A4 | |
| SCHEMBL21767198 | 0.76 | — | — | |
| SCHEMBL6981125 | 0.76 | — | — | |
| SCHEMBL13188717 | 0.73 | NAMPT (0.44) | CYP2C9NAMPTCYP11B1CYP11B2 | |
| SCHEMBL13632447 | 0.73 | CYP2C9 (0.50) | CYP2C9NAMPTCYP11B2ATMHCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2791137-B1 | PYRAZOLOPYRIDINE DERIVATIVES, PREPARATION PROCESS THEREFOR AND THERAPEUTIC USE THEREOF | SANOFI SA (FR) | 2019-01-23 | — | — | EP | disclosed |