Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCRL | Q16602 | 20/20 | 0.58 |
| ▸ | RAMP1 | O60894 | 8/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31084968 | 1.00 | CALCRL (0.58) | CALCRLRAMP1 | |
| SCHEMBL31126005 | 1.00 | CALCRL (0.58) | CALCRLRAMP1 | |
| SCHEMBL29517994 | 1.00 | CALCRL (0.58) | CALCRLRAMP1 | |
| SCHEMBL4571727 | 1.00 | CALCRL (0.58) | CALCRLRAMP1 | |
| SCHEMBL29517777 | 0.89 | CALCRL (0.53) | CALCRLRAMP1 | |
| SCHEMBL22796835 | 0.89 | CALCRL (0.53) | CALCRLRAMP1 | |
| SCHEMBL4567288 | 0.88 | CALCRL (0.58) | CALCRLRAMP1 | |
| SCHEMBL29518081 | 0.87 | CALCRL (0.61) | CALCRLRAMP1 | |
| SCHEMBL3694253 | 0.87 | CALCRL (0.61) | CALCRLRAMP1 | |
| SCHEMBL31084957 | 0.87 | CALCRL (0.61) | CALCRLRAMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2849568-B1 | PROCESS FOR MAKING CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME (US) | 2020-04-15 | — | — | EP | disclosed |
| EP-3430906-A1 | CRYSTALLINE FORMS OF CGRP RECEPTOR ANTAGONISTS | Merck Sharp & Dohme Corp. (US) | 2019-01-23 | — | — | EP | disclosed |