Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.77 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.68 |
| ▸ | TP53 | P04637 | 1/20 | 0.68 |
| ▸ | HTT | P42858 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | DHODH | Q02127 | 2/20 | 0.50 |
| ▸ | GPR3 | P46089 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | ERN1 | O75460 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13957825 | 0.87 | PDE10A (1.00) | PDE10AHSD17B10TP53HTTKMT2A | |
| SCHEMBL15487702 | 0.84 | HSD17B10 (0.66) | PDE10AHSD17B10TP53HTTKMT2A | |
| SCHEMBL20659212 | 0.84 | PDE10A (0.75) | PDE10AHSD17B10TP53HTTKMT2A | |
| SCHEMBL29864783 | 0.84 | PDE10A (0.75) | PDE10AHSD17B10TP53HTTKMT2A | |
| SCHEMBL29952587 | 0.84 | HSD17B10 (0.71) | PDE10AHSD17B10TP53HTTKMT2A | |
| SCHEMBL20669707 | 0.84 | PDE10A (0.75) | PDE10AHSD17B10TP53HTTKMT2A | |
| SCHEMBL20669570 | 0.84 | PDE10A (0.75) | PDE10AHSD17B10TP53HTTKMT2A | |
| SCHEMBL12220557 | 0.83 | HSD17B10 (0.62) | PDE10AHSD17B10TP53HTTKMT2A | |
| SCHEMBL21878637 | 0.81 | MEN1 (0.75) | PDE10AHSD17B10TP53HTTKMT2A | |
| SCHEMBL6654332 | 0.81 | HSD17B10 (1.00) | PDE10AHSD17B10TP53HTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019016269-A1 | AMINE OR (THIO)AMIDE CONTAINING LXR MODULATORS | PHENEX-FXR GMBH (DE) | 2019-01-24 | — | — | WO | disclosed |