Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 4/20 | 0.50 |
| ▸ | TNF | P01375 | 3/20 | 0.43 |
| ▸ | LITAF | Q99732 | 3/20 | 0.43 |
| ▸ | EGFR | P00533 | 4/20 | 0.41 |
| ▸ | SRC | P12931 | 3/20 | 0.41 |
| ▸ | CNR1 | P21554 | 2/20 | 0.40 |
| ▸ | CNR2 | P34972 | 2/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 2/20 | 0.39 |
| ▸ | ABL2 | P42684 | 2/20 | 0.39 |
| ▸ | DGAT2 | Q96PD7 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29785409 | 1.00 | PIK3CA (0.50) | PIK3CATNFLITAFEGFRSRC | |
| SCHEMBL29785435 | 0.88 | PIK3CA (0.51) | PIK3CATNFLITAFEGFRSRC | |
| SCHEMBL20674135 | 0.88 | PIK3CA (0.51) | PIK3CATNFLITAFEGFRSRC | |
| SCHEMBL16414948 | 0.85 | PIK3CA (0.49) | PIK3CATNFLITAF | |
| SCHEMBL16246123 | 0.82 | FGFR1 (0.49) | SRC | |
| SCHEMBL24080467 | 0.80 | FGFR4 (0.48) | PIK3CATNFLITAF | |
| SCHEMBL20733924 | 0.80 | PIK3CA (0.44) | PIK3CATNFLITAF | |
| SCHEMBL4088961 | 0.80 | PIK3CA (0.44) | PIK3CATNFLITAFEGFRCNR1 | |
| SCHEMBL4151029 | 0.80 | PIK3CA (0.39) | PIK3CAEGFRSRCMAPK14 | |
| SCHEMBL4147585 | 0.79 | PIK3CA (0.38) | PIK3CAEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110914267-B | Pyrimidopyridone or pyridopyridone compound and application thereof | 江苏奥赛康药业有限公司 | 2022-07-12 | — | — | CN | disclosed |
| CN-110914267-A | Pyrimidopyridone or pyridopyridone compound and application thereof | 江苏奥赛康药业有限公司 | 2020-03-24 | — | — | CN | disclosed |
| WO-2019015593-A1 | PYRIMIDOPYRIDONE OR PYRIDOPYRIDONE COMPOUND AND USE THEREOF | 江苏奥赛康药业股份有限公司 | 2019-01-24 | — | — | WO | disclosed |