Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 10/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KDM5A | P29375 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | HTR1B | P28222 | 1/20 | 0.34 |
| ▸ | HTR1F | P30939 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | HTR7 | P34969 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21611280 | 0.81 | SMN1; SMN2 (0.55) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL20116305 | 0.80 | USP7 (0.41) | PIK3CDSMN1; SMN2ALDH1A1 | |
| SCHEMBL22358408 | 0.77 | KHK (0.44) | MAPK8MAPK9MAPK10ALDH1A1HTR1A | |
| SCHEMBL20116406 | 0.75 | SMN1; SMN2 (0.48) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL22358315 | 0.75 | PIK3CD (0.40) | PIK3CDSMN1; SMN2ALDH1A1 | |
| SCHEMBL20676547 | 0.75 | PIK3CD (0.40) | PIK3CDSMN1; SMN2ALDH1A1 | |
| SCHEMBL22358352 | 0.73 | NAMPT (0.47) | HTR1AHTR1BHTR1F | |
| SCHEMBL20676673 | 0.71 | SMN1; SMN2 (0.39) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL26997918 | 0.70 | IRAK4 (0.39) | SMN1; SMN2MAPK8MAPK9MAPK10ALDH1A1 | |
| SCHEMBL20674704 | 0.70 | USP30 (0.36) | PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019209948-A9 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2020-01-02 | — | — | WO | disclosed |
| WO-2019018795-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS (US) | 2019-01-24 | — | — | WO | disclosed |