Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 10/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2065453 | 0.89 | NTRK1 (0.31) | NTRK1 | |
| SCHEMBL2066204 | 0.87 | NTRK1 (0.43) | NTRK1JAK3BTK | |
| SCHEMBL2066843 | 0.87 | NTRK1 (0.43) | NTRK1JAK3BTK | |
| SCHEMBL2066201 | 0.87 | NTRK1 (0.43) | NTRK1JAK3BTK | |
| SCHEMBL2066846 | 0.86 | NTRK1 (0.37) | NTRK1JAK3BTK | |
| SCHEMBL2065278 | 0.86 | NTRK1 (0.37) | NTRK1JAK3BTK | |
| SCHEMBL2066215 | 0.86 | NTRK1 (0.35) | NTRK1JAK3BTK | |
| SCHEMBL2065722 | 0.85 | NTRK1 (0.38) | NTRK1JAK3BTK | |
| SCHEMBL2065432 | 0.85 | KDR (0.39) | NTRK1JAK3BTK | |
| SCHEMBL2065587 | 0.85 | KDR (0.35) | NTRK1JAK3BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8148400-B2 | Thiazolyl compounds useful as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-04-03 | — | — | US | disclosed |