Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20690383 | 1.00 | NR1H2 (0.47) | NR1H2USP2SMN1; SMN2HRH3HPGD | |
| SCHEMBL20690384 | 1.00 | NR1H2 (0.47) | NR1H2USP2SMN1; SMN2HRH3HPGD | |
| SCHEMBL25789879 | 0.88 | NR1H2 (0.46) | NR1H2USP2SMN1; SMN2HRH3HPGD | |
| SCHEMBL21911293 | 0.84 | NR1H2 (0.51) | NR1H2USP2SMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL1189634 | 0.84 | NR1H2 (0.51) | NR1H2USP2SMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL1538186 | 0.84 | NR1H2 (0.51) | NR1H2USP2SMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL1567999 | 0.81 | NR1H2 (0.46) | NR1H2USP2SMN1; SMN2HRH3HPGD | |
| SCHEMBL26551515 | 0.81 | NR1H2 (0.47) | NR1H2USP2SMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL13744728 | 0.81 | NR1H2 (0.47) | NR1H2USP2SMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL19701967 | 0.80 | TSHR (0.48) | USP2SMN1; SMN2ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019020657-A1 | PYRIDINE-3-SULFONAMIDE COMPOUNDS AS PI3-KINASE INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-01-31 | — | — | WO | disclosed |