Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 7/20 | 0.38 |
| ▸ | RAB9A | P51151 | 5/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL206544 | 0.86 | PARP1 (0.43) | PARP1HSD11B1 | |
| SCHEMBL206489 | 0.81 | PARP1 (0.50) | PARP1 | |
| SCHEMBL206737 | 0.79 | LCK (0.46) | RAB9ANPC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL205914 | 0.77 | TLR9 (0.47) | PARP1 | |
| SCHEMBL205786 | 0.74 | PARP1 (0.49) | PARP1LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL203957 | 0.74 | PARP1 (0.57) | PARP1LMNAPOLB | |
| SCHEMBL207485 | 0.72 | PARP1 (0.50) | PARP1LMNAPOLB | |
| SCHEMBL205132 | 0.72 | PARP1 (0.55) | PARP1 | |
| SCHEMBL205714 | 0.71 | PARP1 (0.49) | PARP1LMNAPOLB | |
| SCHEMBL206528 | 0.71 | SMN1; SMN2 (0.53) | LMNAPOLBRAB9ANPC1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088760-B2 | Benzoxazole carboxamide inhibitors of poly(ADP-ribose)polymerase (PARP) | BIOMARIN PHARMACEUTICAL INC. (US) | 2012-01-03 | — | — | US | claimed |
| US-8088760-B2 | Benzoxazole carboxamide inhibitors of poly(ADP-ribose)polymerase (PARP) | BIOMARIN PHARMACEUTICAL INC. (US) | 2012-01-03 | — | — | US | disclosed |