Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK5 | Q8IW41 | 13/20 | 0.61 |
| ▸ | FYN | P06241 | 1/20 | 0.49 |
| ▸ | TTK | P33981 | 5/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5576249 | 0.84 | MAPKAPK5 (0.51) | MAPKAPK5FYNTTKAURKA | |
| SCHEMBL2068694 | 0.79 | MAPKAPK5 (0.61) | MAPKAPK5TTK | |
| SCHEMBL4392693 | 0.77 | MAPKAPK5 (0.68) | MAPKAPK5FYNTTK | |
| SCHEMBL5575558 | 0.77 | MAPKAPK5 (0.49) | MAPKAPK5FYNTTKAURKA | |
| SCHEMBL4393746 | 0.76 | MAPKAPK5 (0.72) | MAPKAPK5TTK | |
| SCHEMBL5576245 | 0.76 | TTK (0.54) | MAPKAPK5TTK | |
| SCHEMBL5575646 | 0.76 | MAPKAPK5 (0.48) | MAPKAPK5FYNTTKAURKA | |
| SCHEMBL2068099 | 0.76 | MAPKAPK5 (1.00) | MAPKAPK5FYNTTKAURKAAURKB | |
| SCHEMBL14387503 | 0.72 | MAPKAPK5 (0.82) | MAPKAPK5FYNTTK | |
| SCHEMBL10211808 | 0.71 | MAPKAPK5 (0.81) | MAPKAPK5FYNTTKAURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7893058-B2 | Imidazolopyrazine compounds useful for the treatment of degenerative and inflammatory diseases | JANSSEN PHARMACEUTICA NV (BE) | 2011-02-22 | — | — | US | claimed |