Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 19/20 | 0.54 |
| ▸ | JAK1 | P23458 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20697052 | 0.92 | TYK2 (0.55) | TYK2JAK1 | |
| SCHEMBL20688683 | 0.88 | TYK2 (0.48) | TYK2JAK1 | |
| SCHEMBL20688966 | 0.85 | TYK2 (0.59) | TYK2JAK1 | |
| SCHEMBL20697406 | 0.85 | TYK2 (0.57) | TYK2JAK1 | |
| SCHEMBL21947993 | 0.84 | TYK2 (0.54) | TYK2 | |
| SCHEMBL20689108 | 0.84 | TYK2 (0.60) | TYK2 | |
| SCHEMBL20689402 | 0.84 | TYK2 (0.70) | TYK2JAK1 | |
| SCHEMBL20696946 | 0.84 | TYK2 (0.71) | TYK2JAK1 | |
| SCHEMBL20697382 | 0.83 | TYK2 (0.58) | TYK2JAK1 | |
| SCHEMBL21246008 | 0.82 | TYK2 (0.68) | TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020081508-A1 | TYK2 INHIBITORS AND USES THEREOF | NIMBUS LAKSHMI, INC. (US) | 2020-04-23 | — | — | WO | disclosed |
| WO-2019023468-A1 | TYK2 INHIBITORS AND USES THEREOF | NIMBUS LAKSHMI, INC. (US) | 2019-01-31 | — | — | WO | disclosed |