Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | TYK2 | P29597 | 8/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | STAT3 | P40763 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20688791 | 0.86 | TYK2 (0.45) | TYK2 | |
| SCHEMBL20688849 | 0.76 | TYK2 (0.60) | TYK2 | |
| SCHEMBL21948511 | 0.74 | TYK2 (0.69) | TYK2STAT3 | |
| SCHEMBL20687954 | 0.73 | TYK2 (0.61) | ALDH1A1TYK2 | |
| SCHEMBL21227341 | 0.72 | TYK2 (0.51) | ALDH1A1KDM4EHPGDTYK2USP2 | |
| SCHEMBL20687891 | 0.72 | TYK2 (0.70) | TYK2 | |
| SCHEMBL22092692 | 0.72 | POLB (0.44) | ALDH1A1KDM4EHPGDTYK2TSHR | |
| SCHEMBL20697305 | 0.70 | TYK2 (0.69) | TYK2 | |
| SCHEMBL25171145 | 0.70 | KDM4E (0.37) | ALDH1A1KDM4EHPGDUSP2TSHR | |
| SCHEMBL30309818 | 0.70 | KDM4E (0.46) | ALDH1A1KDM4ETDP1PIM1CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019023468-A1 | TYK2 INHIBITORS AND USES THEREOF | NIMBUS LAKSHMI, INC. (US) | 2019-01-31 | — | — | WO | disclosed |