Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 6/20 | 0.52 |
| ▸ | CDK2 | P24941 | 3/20 | 0.36 |
| ▸ | CDK9 | P50750 | 2/20 | 0.36 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.34 |
| ▸ | CDK7 | P50613 | 2/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.34 |
| ▸ | CCNH | P51946 | 1/20 | 0.34 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.34 |
| ▸ | SMPD3 | Q9NY59 | 3/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20689162 | 0.88 | TYK2 (0.61) | TYK2P2RY12 | |
| SCHEMBL20696967 | 0.87 | TYK2 (0.69) | TYK2P2RY12 | |
| SCHEMBL21227420 | 0.84 | TYK2 (0.57) | TYK2CDK2P2RY12 | |
| SCHEMBL20678825 | 0.69 | TYK2 (0.82) | TYK2 | |
| SCHEMBL20678831 | 0.69 | TYK2 (0.82) | TYK2 | |
| SCHEMBL20687722 | 0.69 | TYK2 (0.82) | TYK2 | |
| SCHEMBL20687721 | 0.68 | TYK2 (1.00) | TYK2 | |
| SCHEMBL20688292 | 0.68 | TYK2 (0.60) | TYK2CDK2SMPD3 | |
| SCHEMBL20697163 | 0.65 | TYK2 (0.49) | TYK2P2RY12SMPD3 | |
| SCHEMBL20688036 | 0.64 | TYK2 (0.56) | TYK2SMPD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019023468-A1 | TYK2 INHIBITORS AND USES THEREOF | NIMBUS LAKSHMI, INC. (US) | 2019-01-31 | — | — | WO | disclosed |