Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 2/20 | 0.45 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 3/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.35 |
| ▸ | APAF1 | O14727 | 1/20 | 0.35 |
| ▸ | TDP2 | O95551 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12889428 | 0.80 | PDE4A (0.42) | ELANEPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL27681105 | 0.79 | ELANE (0.43) | ELANESLC22A12PDE4AAXLKCNH2 | |
| SCHEMBL27251595 | 0.79 | PSMB5 (0.44) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| SCHEMBL12874831 | 0.79 | PDE4A (0.41) | ELANEPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL26628372 | 0.79 | RET (0.43) | PDE4APDE4BPDE4CPDE4DRET | |
| SCHEMBL31725474 | 0.79 | RET (0.43) | PDE4APDE4BPDE4CPDE4DRET | |
| SCHEMBL26354834 | 0.79 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DRET | |
| SCHEMBL414164 | 0.78 | ELANE (0.42) | ELANESLC22A12PDE4AAXLKCNH2 | |
| SCHEMBL1892910 | 0.78 | DYRK1A (0.49) | ELANESLC22A12AXLGSK3BMEN1 | |
| SCHEMBL30731192 | 0.78 | DYRK1A (0.49) | ELANESLC22A12AXLGSK3BMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022257568-A1 | AZAINDOLE PYRIMIDINAMINE HETEROCYCLIC COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 中国药科大学 | 2022-12-15 | — | — | WO | disclosed |
| WO-2019023468-A1 | TYK2 INHIBITORS AND USES THEREOF | NIMBUS LAKSHMI, INC. (US) | 2019-01-31 | — | — | WO | disclosed |