Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 19/20 | 0.81 |
| ▸ | JAK1 | P23458 | 2/20 | 0.69 |
| ▸ | JAK2 | O60674 | 1/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.69 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.69 |
| ▸ | STAT3 | P40763 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20689693 | 0.91 | TYK2 (0.74) | TYK2JAK1JAK2CYP3A4CYP2C19 | |
| SCHEMBL20697080 | 0.91 | TYK2 (0.74) | TYK2JAK1JAK2CYP3A4CYP2C19 | |
| SCHEMBL20689691 | 0.91 | TYK2 (0.74) | TYK2JAK1JAK2CYP3A4CYP2C19 | |
| SCHEMBL20689690 | 0.89 | TYK2 (1.00) | TYK2JAK1JAK2CYP3A4CYP2C19 | |
| SCHEMBL20688983 | 0.89 | TYK2 (1.00) | TYK2JAK1JAK2CYP3A4CYP2C19 | |
| SCHEMBL20688739 | 0.89 | TYK2 (1.00) | TYK2JAK1JAK2CYP3A4CYP2C19 | |
| SCHEMBL20697079 | 0.89 | TYK2 (1.00) | TYK2JAK1JAK2CYP3A4CYP2C19 | |
| SCHEMBL21947232 | 0.84 | TYK2 (0.75) | TYK2JAK1JAK2CYP3A4CYP2C19 | |
| SCHEMBL21961707 | 0.84 | TYK2 (0.75) | TYK2JAK1JAK2CYP3A4CYP2C19 | |
| SCHEMBL20689694 | 0.83 | TYK2 (0.63) | TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019023468-A1 | TYK2 INHIBITORS AND USES THEREOF | NIMBUS LAKSHMI, INC. (US) | 2019-01-31 | — | — | WO | disclosed |