Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 13/20 | 0.39 |
| ▸ | EGFR | P00533 | 3/20 | 0.39 |
| ▸ | RIPK2 | O43353 | 3/20 | 0.36 |
| ▸ | ABL1 | P00519 | 2/20 | 0.36 |
| ▸ | ABL2 | P42684 | 2/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | ADK | P55263 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30813452 | 0.87 | SRC (0.39) | SRCEGFRRIPK2ABL1ABL2 | |
| SCHEMBL30813365 | 0.83 | SRC (0.38) | SRCEGFRABL1ABL2 | |
| SCHEMBL27217948 | 0.82 | SRC (0.39) | SRCEGFRRIPK2ABL1ABL2 | |
| SCHEMBL26725853 | 0.80 | JAK2 (0.43) | SRCEGFRABL1PDPK1 | |
| SCHEMBL21221307 | 0.80 | USP30 (0.39) | SRCEGFRRIPK2ABL1ABL2 | |
| SCHEMBL30813372 | 0.80 | LCK (0.35) | SRCEGFRABL1PDPK1 | |
| SCHEMBL30813374 | 0.79 | SRC (0.49) | SRCEGFRABL1ABL2 | |
| SCHEMBL27217725 | 0.79 | SRC (0.49) | SRCEGFRABL1ABL2 | |
| SCHEMBL27217916 | 0.78 | SRC (0.38) | SRCEGFRABL1ABL2 | |
| SCHEMBL30813645 | 0.78 | SSTR4 (0.35) | SRCPDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019021208-A1 | INDAZOLE DERIVATIVES USEFUL AS PERK INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-01-31 | — | — | WO | disclosed |