Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 2/20 | 0.43 |
| ▸ | CES1 | P23141 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MME | P08473 | 1/20 | 0.40 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL74366 | 0.80 | SRC (0.56) | SRCCYP2D6LMNAMAPK1CES2 | |
| Chloromethane SCHEMBL27726358 | 0.79 | SRC (0.50) | SRCCYP2D6LMNAMAPK1CES2 | |
| SCHEMBL9035355 | 0.79 | BRD4 (0.45) | CYP2D6LMNAMAPK1CES2CES1 | |
| SCHEMBL27913889 | 0.78 | CYP2D6 (0.48) | SRCCYP2D6LMNAMAPK1CES2 | |
| Hydrochloric Acid SCHEMBL8340022 | 0.78 | SRC (0.54) | SRCCYP2D6LMNAMAPK1CES2 | |
| SCHEMBL11798536 | 0.77 | CYP3A4 (0.40) | KMT2A | |
| SCHEMBL11249181 | 0.77 | HDAC3 (0.44) | LMNACES2CES1HDAC3HDAC4 | |
| SCHEMBL9781797 | 0.76 | SRC (0.46) | SRCCYP2D6LMNAMAPK1CES2 | |
| SCHEMBL5463791 | 0.76 | EPHX1 (0.48) | SRCCYP2D6LMNAMAPK1CES2 | |
| SCHEMBL7343000 | 0.76 | CYP2D6 (0.46) | SRCCYP2D6LMNAMAPK1CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105085337-A | (Z)-3-dimethylamino-alpha-mercaptophenyl-alpha,beta-unsaturated amide compound and preparing method thereof | ENGINEERING AND TECHNOLOGY INST OF LUNAN COAL CHEMICAL ENGINEERING | 2015-11-25 | — | — | CN | claimed |
| JP-11209371-A | — | — | None | — | — | JP | disclosed |
| CN-105085337-A | (Z)-3-dimethylamino-alpha-mercaptophenyl-alpha,beta-unsaturated amide compound and preparing method thereof | ENGINEERING AND TECHNOLOGY INST OF LUNAN COAL CHEMICAL ENGINEERING | 2015-11-25 | — | — | CN | disclosed |
| US-7906546-B2 | Tetrahydrocarbazoles and derivatives | HOFFMANN-LA ROCHE INC. (US) | 2011-03-15 | — | — | US | disclosed |
| US-20100216833-A1 | TETRAHYDROCARBAZOLES AND DERIVATIVES | DEHMLOW HENRIETTA | 2010-08-26 | — | — | US | disclosed |
| US-20080293745-A1 | New amino-alkyl-amide derivatives as CCR3 receptor ligands | SANOFI-AVENTIS (FR) | 2008-11-27 | — | — | US | disclosed |
| EP-1732892-B1 | TETRAHYDROCARBAZOLES AND DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2008-09-17 | — | — | EP | disclosed |
| EP-1931627-A1 | AMINO-ALKYL-AMIDE DERIVATIVES AS CCR3 RECEPTOR LIGANDS | Sanofi-Aventis (FR) | 2008-06-18 | — | — | EP | disclosed |
| WO-2007034251-A1 | AMINO-ALKYL-AMIDE DERIVATIVES AS CCR3 RECEPTOR LIGANDS | SANOFI-AVENTIS (FR) | 2007-03-29 | — | — | WO | disclosed |
| EP-1732892-A1 | TETRAHYDROCARBAZOLES AND DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2006-12-20 | — | — | EP | disclosed |
| US-4778884-A | REACTING TRIFLUOROMETHYLSULFONYLOXY COMPOUND WITH LITHIUM HALIDE IN APROTIC POLAR SOLVENT | PRESIDENT & FELLOWS OF HARVARD COLLEGE (US) | 1988-10-18 | — | — | US | disclosed |
| US-4775752-A | Process and intermediates for beta-lactam antibiotics | THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 1988-10-04 | — | — | US | disclosed |
| US-4734495-A | Process and intermediates for beta-lactam antibiotics | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 1988-03-29 | — | — | US | disclosed |
| US-4673737-A | ANTIBIOTICS/ | HARVARD UNIVERSITY (US) | 1987-06-16 | — | — | US | disclosed |
| US-4665171-A | CARBACEPHALOSPORINS | HARVARD UNIVERSITY (US) | 1987-05-12 | — | — | US | disclosed |
| EP-0211540-A1 | Intermediates and process for antibiotics | THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 1987-02-25 | — | — | EP | disclosed |
| EP-0209352-A2 | Process and intermediates for beta-lactam antibiotics | THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 1987-01-21 | — | — | EP | disclosed |
| US-4346076-A | Bis-tetrazoylmethyl substituted cephalosporin antibiotics | ELI LILLY AND COMPANY (US) | 1982-08-24 | — | — | US | disclosed |
| EP-0048169-A2 | Bis-tetrazoylmethyl substituted cephalosporin antibiotics, their preparation and pharmaceutical formulations containing them | ELI LILLY AND COMPANY (US) | 1982-03-24 | — | — | EP | disclosed |
| US-3988325-A | 7-Carboxy or 2,2,2-trichloroethoxy carbonyl- cephalosporins | ELI LILLY AND COMPANY (US) | 1976-10-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216833-A1 | TETRAHYDROCARBAZOLES AND DERIVATIVES | NR1H3, NR1H2, NR1H4 | SRC 3330/4885CYP2D6 1092/4885LMNA 2529/4885 |
| US-20080293745-A1 | New amino-alkyl-amide derivatives as CCR3 receptor ligands | CCR3, CCR1, CCR4 | SRC 3285/4885CYP2D6 2824/4885LMNA 3402/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.