Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 20/20 | 0.42 |
| ▸ | SCN5A | Q14524 | 4/20 | 0.41 |
| ▸ | SCN1A | P35498 | 2/20 | 0.41 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.41 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.41 |
| ▸ | SCN7A | Q01118 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20697827 | 1.00 | SCN9A (0.42) | SCN9ASCN5ASCN1ASCN2ASCN8A | |
| SCHEMBL20697678 | 0.85 | SCN9A (0.42) | SCN9ASCN5ASCN1ASCN2ASCN8A | |
| SCHEMBL20697628 | 0.85 | SCN9A (0.42) | SCN9ASCN5ASCN1ASCN2ASCN8A | |
| SCHEMBL20697918 | 0.85 | SCN9A (0.42) | SCN9ASCN5ASCN1ASCN2ASCN8A | |
| SCHEMBL20697639 | 0.83 | SCN9A (0.44) | SCN9ASCN5ASCN1ASCN2ASCN8A | |
| SCHEMBL20697624 | 0.82 | SCN9A (0.41) | SCN9ASCN5ASCN1ASCN2ASCN8A | |
| SCHEMBL20697924 | 0.81 | SCN9A (0.42) | SCN9ASCN5ASCN1ASCN2ASCN8A | |
| SCHEMBL21075495 | 0.81 | SCN9A (0.47) | SCN9ASCN5ASCN1ASCN2ASCN8A | |
| SCHEMBL19084022 | 0.80 | SCN9A (0.43) | SCN9ASCN5ASCN1ASCN2ASCN8A | |
| SCHEMBL20697742 | 0.77 | SCN9A (0.41) | SCN9ASCN5ASCN1ASCN2ASCN8A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11149002-B2 | Therapeutic compounds and methods of use thereof | GENENTECH, INC. (US) | 2021-10-19 | — | — | US | disclosed |
| US-20210078947-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2021-03-18 | — | — | US | disclosed |
| US-20190031607-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2019-01-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11149002-B2 | Therapeutic compounds and methods of use thereof | RDX, C1R, MTX1 | SCN9A 2337/4885SCN5A 1598/4885SCN1A 1166/4885 |
| US-20190031607-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | RDX, C1R, MTX1 | SCN9A 2337/4885SCN5A 1598/4885SCN1A 1166/4885 |
| US-20210078947-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | RDX, C1R, MTX1 | SCN9A 2337/4885SCN5A 1598/4885SCN1A 1166/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.