SCHEMBL2070144

SCHEMBL2070144

CCC(=O)C(C)(C)[C@H](CCO[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16796805 1.00
SCHEMBL7002111 0.84
SCHEMBL6599047 0.84
SCHEMBL6599051 0.84
SCHEMBL14113110 0.81
SCHEMBL3446978 0.78
SCHEMBL5743955 0.78
SCHEMBL5653171 0.78
SCHEMBL2071886 0.77
SCHEMBL3447667 0.77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2015087351-A2 PROCESS FOR THE PREPARATION OF (1S,3S,7S,10R,11S,12S,16R)-7,11-DIHYDROXY-8,8,10,12,16-PENTAMETHYL-3-[(1E)-1-METHYL-2-(2-METHYL-4-THIAZOLYL)ETHENYL]-17-OXA-4-AZABICYCLO[14.1.0]HEPTADECANE-5,9-DIONE AND INTERMEDIATES THEREOF MSN LABORATORIES PRIVATE LIMITED (IN) 2015-06-18 WO claimed
US-6605726-B1 Method for producing epothilone B and derivatives, and intermediate products for this method SCHERING AG (DE) 2003-08-12 US claimed
WO-2015087351-A2 PROCESS FOR THE PREPARATION OF (1S,3S,7S,10R,11S,12S,16R)-7,11-DIHYDROXY-8,8,10,12,16-PENTAMETHYL-3-[(1E)-1-METHYL-2-(2-METHYL-4-THIAZOLYL)ETHENYL]-17-OXA-4-AZABICYCLO[14.1.0]HEPTADECANE-5,9-DIONE AND INTERMEDIATES THEREOF MSN LABORATORIES PRIVATE LIMITED (IN) 2015-06-18 WO disclosed
WO-2015087351-A2 PROCESS FOR THE PREPARATION OF (1S,3S,7S,10R,11S,12S,16R)-7,11-DIHYDROXY-8,8,10,12,16-PENTAMETHYL-3-[(1E)-1-METHYL-2-(2-METHYL-4-THIAZOLYL)ETHENYL]-17-OXA-4-AZABICYCLO[14.1.0]HEPTADECANE-5,9-DIONE AND INTERMEDIATES THEREOF MSN LABORATORIES PRIVATE LIMITED (IN) 2015-06-18 WO disclosed
US-8435983-B2 Conformationally restrained epothilone analogues as anti-leukemic agents THE UNIVERSITY OF TOLEDO (US) 2013-05-07 US disclosed
US-8435983-B2 Conformationally restrained epothilone analogues as anti-leukemic agents THE UNIVERSITY OF TOLEDO (US) 2013-05-07 US disclosed
US-8435983-B2 Conformationally restrained epothilone analogues as anti-leukemic agents THE UNIVERSITY OF TOLEDO (US) 2013-05-07 US disclosed
US-20110301183-A1 CHEMICAL SYNTHESIS OF A HIGHLY POTENT EPOTHILONE NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2011-12-08 US disclosed
US-20110301183-A1 CHEMICAL SYNTHESIS OF A HIGHLY POTENT EPOTHILONE NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2011-12-08 US disclosed
US-7893268-B2 Epithiolone analogues UNIVERSITY OF TOLEDO (US) 2011-02-22 US disclosed
US-20100324094-A1 Conformationally Restrained Epothilone Analogues as Anti-Leukemic Agents THE UNIVERSITY OF TOLEDO (US) 2010-12-23 US disclosed
US-6605726-B1 Method for producing epothilone B and derivatives, and intermediate products for this method SCHERING AG (DE) 2003-08-12 US disclosed
EP-1282618-A2 9-OXA-EPOTHILON DERIVATIVES, METHOD FOR THE PRODUCTION AND USE THEREOF IN PHARMACEUTICAL PREPARATIONS Schering Aktiengesellschaft (DE) 2003-02-12 EP disclosed
EP-1121364-B1 METHOD FOR PRODUCING EPOTHILONE B AND DERIVATIVES THEREOF SCHERING AG (DE) 2003-01-08 EP disclosed
EP-1150980-A2 16-HALOGEN-EPOTHILONE DERIVATIVES, METHOD FOR PRODUCING THEM AND THEIR PHARMACEUTICAL USE SCHERING AKTIENGESELLSCHAFT (DE) 2001-11-07 EP disclosed
WO-2001081341-A2 9-OXA-EPOTHILON DERIVATIVES, METHOD FOR THE PRODUCTION AND USE THEREOF IN PHARMACEUTICAL PREPARATIONS SCHERING AKTIENGESELLSCHAFT (DE) 2001-11-01 WO disclosed
EP-1121364-A1 METHOD FOR PRODUCING EPOTHILONE B AND DERIVATIVES, AND INTERMEDIATE PRODUCTS FOR THIS METHOD Schering Aktiengesellschaft (DE) 2001-08-08 EP disclosed
WO-2000049021-A2 16-HALOGEN-EPOTHILONE DERIVATIVES, METHOD FOR PRODUCING THEM AND THEIR PHARMACEUTICAL USE SCHERING AKTIENGESELLSCHAFT (DE) 2000-08-24 WO disclosed
WO-2000049020-A2 NOVEL EPOTHILON DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR PHARMACEUTICAL APPLICATION SCHERING AKTIENGESELLSCHAFT (DE) 2000-08-24 WO disclosed
WO-2000023452-A1 METHOD FOR PRODUCING EPOTHILONE B AND DERIVATIVES, AND INTERMEDIATE PRODUCTS FOR THIS METHOD SCHERING AKTIENGESELLSCHAFT (DE) 2000-04-27 WO disclosed