SCHEMBL2070243

SCHEMBL2070243

COc1ccc(C(=O)N(C)Cc2cc(Cl)cc(-c3cc(-c4cc(C(F)(F)F)ccc4Cl)c(C#N)c(=O)[nH]3)c2O)cc1

nearest known ligand 0.70

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
BIRC5 O15392 19/20 0.70
PIM1 P11309 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2071630 0.91 BIRC5 (0.73) BIRC5
SCHEMBL2070844 0.87 BIRC5 (0.78) BIRC5
SCHEMBL2072560 0.87 BIRC5 (0.69) BIRC5
SCHEMBL2070821 0.84 BIRC5 (0.69) BIRC5
SCHEMBL2071751 0.83 BIRC5 (0.76) BIRC5
SCHEMBL2071966 0.83 BIRC5 (0.66) BIRC5
SCHEMBL2070548 0.83 BIRC5 (0.68) BIRC5
SCHEMBL2070174 0.83 BIRC5 (0.63) BIRC5
SCHEMBL2070068 0.82 BIRC5 (1.00) BIRC5
SCHEMBL2072312 0.82 BIRC5 (0.63) BIRC5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7910742-B2 Survivin inhibitors ABBOTT LABORATORIES (US) 2011-03-22 US disclosed
US-20070072833-A1 Survivin inhibitors ABBVIE INC. 2007-03-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070072833-A1 Survivin inhibitors XIAP, BIRC5, BIRC3 BIRC5 2/4885PIM1 3795/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.