Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 17/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | FBP1 | P09467 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15512714 | 0.96 | HDAC1 (0.75) | HDAC1ALDH1A1HDAC3HDAC2HDAC4 | |
| SCHEMBL15512715 | 0.96 | HDAC1 (0.75) | HDAC1ALDH1A1HDAC3HDAC2HDAC4 | |
| Trifluoroacetic Acid SCHEMBL2071012 | 0.95 | HDAC1 (0.78) | HDAC1ALDH1A1HDAC3HDAC2HDAC4 | |
| SCHEMBL2070516 | 0.91 | HDAC1 (0.66) | HDAC1ALDH1A1HDAC3HDAC2HDAC4 | |
| SCHEMBL15512493 | 0.90 | HDAC1 (0.83) | HDAC1ALDH1A1HDAC3HDAC2HDAC4 | |
| SCHEMBL15512494 | 0.90 | HDAC1 (0.83) | HDAC1ALDH1A1HDAC3HDAC2HDAC4 | |
| Trifluoroacetic Acid SCHEMBL2074750 | 0.89 | HDAC1 (0.70) | HDAC1HDAC3HDAC2HDAC4HDAC6 | |
| Trifluoroacetic Acid SCHEMBL2072072 | 0.87 | HDAC1 (0.91) | HDAC1HDAC3HDAC2HDAC4HDAC6 | |
| Trifluoroacetic Acid SCHEMBL2074219 | 0.85 | HDAC1 (0.80) | HDAC1 | |
| Trifluoroacetic Acid SCHEMBL2074040 | 0.85 | HDAC1 (0.79) | HDAC1HDAC3HDAC2HDAC4HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828171-B1 | HETEROCYCLE DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | ANGELETTI P IST RICHERCHE BIO (IT) | 2014-03-12 | — | — | EP | disclosed |
| US-7863294-B2 | Heterocycle derivatives as histone deacetylase (HDAC) inhibitors | INSTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2011-01-04 | — | — | US | disclosed |
| US-20090048228-A1 | Heterocycle Derivatives As Histone Deacetylase (Hdac) Inhibitors | MSD ITALIA S.R.L. (IT) | 2009-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090048228-A1 | Heterocycle Derivatives As Histone Deacetylase (Hdac) Inhibitors | HDAC1, HDAC5, HDAC11 | HDAC1 1/4885ALDH1A1 422/4885HDAC3 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.