Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 18/20 | 0.60 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22264107 | 1.00 | KLKB1 (0.60) | KLKB1HRH4HRH3GFER | |
| SCHEMBL20713766 | 0.91 | KLKB1 (0.71) | KLKB1HRH4HRH3 | |
| SCHEMBL20705247 | 0.91 | KLKB1 (0.71) | KLKB1HRH4HRH3 | |
| SCHEMBL31181741 | 0.84 | KLKB1 (0.71) | KLKB1HRH4HRH3 | |
| SCHEMBL20705067 | 0.83 | KLKB1 (0.59) | KLKB1HRH4HRH3GFER | |
| SCHEMBL20705069 | 0.83 | KLKB1 (0.59) | KLKB1HRH4HRH3GFER | |
| SCHEMBL20705172 | 0.81 | KLKB1 (0.53) | KLKB1HRH4HRH3 | |
| SCHEMBL20713722 | 0.81 | KLKB1 (0.53) | KLKB1HRH4HRH3 | |
| SCHEMBL22277305 | 0.81 | KLKB1 (0.69) | KLKB1HRH4HRH3 | |
| SCHEMBL20705114 | 0.79 | KLKB1 (0.60) | KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3661922-A1 | INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF | Dyax Corp. (US) | 2020-06-10 | — | — | EP | disclosed |
| WO-2019028362-A1 | INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF | DYAX CORP. (US) | 2019-02-07 | — | — | WO | disclosed |