Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 16/20 | 0.61 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20713633 | 1.00 | KLKB1 (0.61) | KLKB1PTGS1PTGS2TP53KDM4E | |
| SCHEMBL20705114 | 0.86 | KLKB1 (0.60) | KLKB1 | |
| SCHEMBL20705197 | 0.86 | KLKB1 (0.60) | KLKB1 | |
| SCHEMBL20713766 | 0.86 | KLKB1 (0.71) | KLKB1 | |
| SCHEMBL20705247 | 0.86 | KLKB1 (0.71) | KLKB1 | |
| SCHEMBL22277232 | 0.84 | KLKB1 (0.72) | KLKB1 | |
| SCHEMBL20713810 | 0.82 | PTGS1 (0.51) | KLKB1PTGS1PTGS2TP53KDM4E | |
| SCHEMBL22277235 | 0.80 | KLKB1 (0.46) | KLKB1PTGS1PTGS2TP53KDM4E | |
| SCHEMBL20713767 | 0.80 | KLKB1 (0.47) | KLKB1PTGS1PTGS2TP53KDM4E | |
| SCHEMBL31181741 | 0.78 | KLKB1 (0.71) | KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3661922-A1 | INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF | Dyax Corp. (US) | 2020-06-10 | — | — | EP | disclosed |
| WO-2019028362-A1 | INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF | DYAX CORP. (US) | 2019-02-07 | — | — | WO | disclosed |