SCHEMBL2070633

SCHEMBL2070633

COC(=O)c1ccccc1N1CCCC(OCc2sc(-c3ccc(Cl)cc3)nc2C)C1

nearest known ligand 0.65

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
PPARA Q07869 12/20 0.65
PPARD Q03181 2/20 0.41
PPARG P37231 1/20 0.41
CHRM4 P08173 1/20 0.39
MAPT P10636 5/20 0.39
LMNA P02545 3/20 0.39
TP53 P04637 2/20 0.39
THRB P10828 1/20 0.39
KDM4E B2RXH2 1/20 0.38
POLB P06746 1/20 0.38
TSHR P16473 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
HSD17B10 Q99714 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
FFAR1 O14842 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5189321 0.92 PPARA (0.72) PPARAPPARDPPARGCHRM4KDM4E
SCHEMBL2070323 0.88 PPARA (0.51) PPARAPPARDPPARGCHRM4MAPT
SCHEMBL2069466 0.87 PPARA (0.72) PPARAPPARDPPARGKDM4EPOLB
SCHEMBL2069468 0.87 PPARA (0.72) PPARAPPARDPPARGKDM4EPOLB
SCHEMBL2069428 0.86 PPARA (0.67) PPARAPPARDPPARGCHRM4
SCHEMBL2070498 0.86 PPARA (0.53) PPARAPPARDPPARGMAPTLMNA
SCHEMBL3903355 0.85 PPARA (0.68) PPARAPPARDPPARGCHRM4KDM4E
SCHEMBL2071496 0.85 PPARA (0.64) PPARAPPARDPPARGCHRM4MAPT
SCHEMBL2069037 0.85 PPARA (0.51) PPARAMAPTLMNATP53THRB
SCHEMBL2071399 0.85 PPARA (0.55) PPARAPPARDPPARGLMNATP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7902367-B2 Cyclic amino benzoic acid derivative KYORIN PHARMACEUTICAL CO., LTD. (JP) 2011-03-08 US disclosed
US-7902367-B2 Cyclic amino benzoic acid derivative KYORIN PHARMACEUTICAL CO., LTD. (JP) 2011-03-08 US disclosed
US-7902367-B2 Cyclic amino benzoic acid derivative KYORIN PHARMACEUTICAL CO., LTD. (JP) 2011-03-08 US disclosed
US-20070249580-A1 Novel Cyclic Amino Benzoic Acid Derivative KYORIN PHARMACEUTICAL CO., LTD. (JP) 2007-10-25 US disclosed
US-20070249580-A1 Novel Cyclic Amino Benzoic Acid Derivative KYORIN PHARMACEUTICAL CO., LTD. (JP) 2007-10-25 US disclosed
US-20070249580-A1 Novel Cyclic Amino Benzoic Acid Derivative KYORIN PHARMACEUTICAL CO., LTD. (JP) 2007-10-25 US disclosed
EP-1780210-A1 NOVEL CYCLIC AMINOBENZOIC ACID DERIVATIVE Kyorin Pharmaceutical Co., Ltd. (JP) 2007-05-02 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070249580-A1 Novel Cyclic Amino Benzoic Acid Derivative PPARA, PPARG, PPARD PPARA 1/4885PPARD 3/4885PPARG 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.