Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 1/20 | 0.71 |
| ▸ | DEGS1 | O15121 | 3/20 | 0.62 |
| ▸ | RAB9A | P51151 | 4/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.53 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13716370 | 0.93 | NPY5R (0.64) | NPY5RDEGS1RAB9ANPC1PTGS1 | |
| SCHEMBL13256782 | 0.85 | NPY5R (0.55) | NPY5RDEGS1RAB9ANPC1PTGS1 | |
| SCHEMBL16422569 | 0.85 | NPY5R (0.55) | NPY5RDEGS1RAB9ANPC1PTGS1 | |
| SCHEMBL12203141 | 0.84 | NPY5R (0.60) | NPY5RDEGS1RAB9ANPC1KMT2A | |
| Velneperit SCHEMBL10114559 | 0.84 | NPY5R (1.00) | NPY5RDEGS1RAB9ANPC1PTGS1 | |
| SCHEMBL13840438 | 0.84 | NPY5R (0.77) | NPY5RDEGS1RAB9ANPC1PTGS1 | |
| Velneperit SCHEMBL2806595 | 0.84 | NPY5R (1.00) | NPY5RDEGS1RAB9ANPC1PTGS1 | |
| Velneperit SCHEMBL29355442 | 0.84 | NPY5R (1.00) | NPY5RDEGS1RAB9ANPC1PTGS1 | |
| SCHEMBL13840453 | 0.83 | NPY5R (0.75) | NPY5RDEGS1RAB9ANPC1PTGS1 | |
| SCHEMBL13840450 | 0.83 | NPY5R (0.72) | NPY5RDEGS1RAB9ANPC1PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2888229-B1 | alpha7 NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS AND USES THEREOF | MERCK SHARP & DOHME (US) | 2019-02-06 | — | — | EP | disclosed |