Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 1/20 | 0.40 |
| ▸ | S1PR4 | O95977 | 5/20 | 0.39 |
| ▸ | S1PR5 | Q9H228 | 5/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | CCNC | P24863 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2070811 | 0.86 | CA1 (0.37) | TBXAS1CA1CA2HDAC1CYP1A2 | |
| SCHEMBL2072937 | 0.83 | HDAC1 (0.48) | CA1CA2HDAC1CYP1A2ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL2074779 | 0.79 | HDAC1 (0.44) | TBXAS1S1PR4S1PR5HDAC1S1PR1 | |
| Trifluoroacetic Acid SCHEMBL2070996 | 0.77 | HDAC1 (0.62) | HDAC1HDAC6 | |
| Trifluoroacetic Acid SCHEMBL2073246 | 0.77 | HDAC1 (0.62) | HDAC1HDAC6 | |
| Trifluoroacetic Acid SCHEMBL2074056 | 0.76 | HDAC1 (0.60) | S1PR4S1PR5HDAC1S1PR1HDAC6 | |
| SCHEMBL2071048 | 0.75 | MAPT (0.52) | HDAC1ALDH1A1HPGDTSHRSMN1; SMN2 | |
| SCHEMBL2073408 | 0.72 | HDAC1 (0.48) | TBXAS1S1PR4S1PR5HDAC1HDAC6 | |
| Trifluoroacetic Acid SCHEMBL2075049 | 0.71 | HDAC1 (0.61) | HDAC1HDAC6 | |
| Trifluoroacetic Acid SCHEMBL13730513 | 0.71 | TACR1 (0.52) | HDAC1ALDH1A1CYP3A4CYP2C9HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828171-B1 | HETEROCYCLE DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | ANGELETTI P IST RICHERCHE BIO (IT) | 2014-03-12 | — | — | EP | disclosed |
| US-7863294-B2 | Heterocycle derivatives as histone deacetylase (HDAC) inhibitors | INSTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2011-01-04 | — | — | US | disclosed |
| US-20090048228-A1 | Heterocycle Derivatives As Histone Deacetylase (Hdac) Inhibitors | MSD ITALIA S.R.L. (IT) | 2009-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090048228-A1 | Heterocycle Derivatives As Histone Deacetylase (Hdac) Inhibitors | HDAC1, HDAC5, HDAC11 | TBXAS1 1197/4885S1PR4 4165/4885S1PR5 3632/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.