Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.66 |
| ▸ | MTOR | P42345 | 20/20 | 0.66 |
| ▸ | RICTOR | Q6R327 | 18/20 | 0.66 |
| ▸ | RPTOR | Q8N122 | 18/20 | 0.66 |
| ▸ | MAPKAP1 | Q9BPZ7 | 18/20 | 0.66 |
| ▸ | MLST8 | Q9BVC4 | 18/20 | 0.66 |
| ▸ | PIK3R1 | P27986 | 14/20 | 0.60 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.55 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.55 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.55 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16625493 | 1.00 | PIK3CA (0.66) | PIK3CAMTORRICTORRPTORMAPKAP1 | |
| SCHEMBL16620708 | 1.00 | PIK3CA (0.66) | PIK3CAMTORRICTORRPTORMAPKAP1 | |
| SCHEMBL18011608 | 0.90 | PIK3CA (0.70) | PIK3CAMTORRICTORRPTORMAPKAP1 | |
| SCHEMBL16620711 | 0.90 | PIK3CA (0.70) | PIK3CAMTORRICTORRPTORMAPKAP1 | |
| SCHEMBL16625495 | 0.89 | PIK3CA (0.66) | PIK3CAMTORRICTORRPTORMAPKAP1 | |
| SCHEMBL18431649 | 0.89 | PIK3CA (0.66) | PIK3CAMTORRICTORRPTORMAPKAP1 | |
| SCHEMBL16625652 | 0.89 | PIK3CA (0.66) | PIK3CAMTORRICTORRPTORMAPKAP1 | |
| SCHEMBL16625492 | 0.88 | PIK3CA (0.65) | PIK3CAMTORRICTORRPTORMAPKAP1 | |
| SCHEMBL18431647 | 0.88 | PIK3CA (0.65) | PIK3CAMTORRICTORRPTORMAPKAP1 | |
| SCHEMBL16620856 | 0.88 | PIK3CA (0.65) | PIK3CAMTORRICTORRPTORMAPKAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3052504-B1 | CONFORMATIONALLY RESTRICTED PI3K AND MTOR INHIBITORS | UNIV BASEL (CH) | 2019-02-06 | — | — | EP | disclosed |