Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 18/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20710475 | 0.90 | GBA1 (0.49) | GBA1PIK3CA | |
| SCHEMBL20710486 | 0.86 | GBA1 (0.72) | GBA1 | |
| SCHEMBL20710482 | 0.86 | GBA1 (0.58) | GBA1ALDH1A1 | |
| SCHEMBL20710516 | 0.83 | GBA1 (0.71) | GBA1PIK3CA | |
| SCHEMBL22403105 | 0.79 | GBA1 (0.52) | GBA1PIK3CAALDH1A1 | |
| SCHEMBL20710454 | 0.75 | GBA1 (0.67) | GBA1 | |
| SCHEMBL20710510 | 0.75 | GBA1 (0.75) | GBA1KDM4E | |
| SCHEMBL22403072 | 0.74 | GBA1 (0.76) | GBA1 | |
| SCHEMBL20710433 | 0.74 | GBA1 (0.67) | GBA1 | |
| SCHEMBL20710461 | 0.73 | GBA1 (0.69) | GBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200283444-A1 | SUBSTITUTED FUSED PYRIMIDINE COMPOUNDS AND USES THEREOF | NORTHWESTERN UNIVERSITY | 2020-09-10 | — | — | US | disclosed |
| WO-2019027765-A1 | SUBSTITUTED FUSED PYRIMIDINE COMPOUNDS AND USES THERE | NORTHWESTERN UNIVERSITY (US) | 2019-02-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200283444-A1 | SUBSTITUTED FUSED PYRIMIDINE COMPOUNDS AND USES THEREOF | GBA3, GBA1, GBA2 | GBA1 2/4885PIK3CA 509/4885KDM4E 3271/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.