Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.35 |
| ▸ | TUBB | P07437 | 1/20 | 0.35 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.35 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.35 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.35 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.35 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.35 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.35 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.35 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.35 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.35 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.35 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.35 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.35 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | GRM1 | Q13255 | 3/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16492123 | 1.00 | MAPK8 (0.36) | MAPK8TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL28745223 | 1.00 | MAPK8 (0.36) | MAPK8TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL30063229 | 0.92 | NPC1 (0.37) | MAPK8NPC1RAB9AP2RX7SMN1; SMN2 | |
| SCHEMBL12778710 | 0.92 | NPC1 (0.37) | MAPK8NPC1RAB9AP2RX7SMN1; SMN2 | |
| SCHEMBL19578935 | 0.92 | NPC1 (0.37) | MAPK8NPC1RAB9AP2RX7SMN1; SMN2 | |
| SCHEMBL16470691 | 0.88 | NPC1 (0.39) | MAPK8NPC1RAB9AP2RX7MEN1 | |
| SCHEMBL16492110 | 0.88 | NPC1 (0.39) | MAPK8NPC1RAB9AP2RX7MEN1 | |
| SCHEMBL28417615 | 0.88 | NPC1 (0.39) | MAPK8NPC1RAB9AP2RX7MEN1 | |
| SCHEMBL12845046 | 0.84 | NPC1 (0.37) | MAPK8NPC1RAB9AP2RX7MEN1 | |
| SCHEMBL19143210 | 0.83 | NPC1 (0.38) | MAPK8NPC1RAB9AP2RX7SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7897803-B2 | Cis-alkoxy-substituted spirocyclic 1H-pyrrolidine-2,4-dione derivatives serving as pesticides | BAYER CROPSCIENCE AG (DE) | 2011-03-01 | — | — | US | disclosed |
| US-20100056598-A1 | CIS-ALKOXY-SUBSTITUTED SPIROCYCLIC 1H-PYRROLIDINE-2,4-DIONE DERIVATIVES SERVING AS PESTICIDES | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2010-03-04 | — | — | US | disclosed |
| US-7638547-B2 | Cis-alkoxy-substituted spirocyclic 1H-pyrrolidine-2,4-dione derivatives serving as pesticides | BAYER CROPSCIENCE AG (DE) | 2009-12-29 | — | — | US | disclosed |
| US-20070032539-A1 | Cis-alkoxy-substituted spirocyclic 1-h-pyrrolidine-2,4-dione derivatives serving as pesticides | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2007-02-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056598-A1 | CIS-ALKOXY-SUBSTITUTED SPIROCYCLIC 1H-PYRROLIDINE-2,4-DIONE DERIVATIVES SERVING AS PESTICIDES | DDT, CYP4X1, CDY1; CDY1B | MAPK8 4276/4885TUBB4A 1149/4885TUBB 1096/4885 |
| US-20070032539-A1 | Cis-alkoxy-substituted spirocyclic 1-h-pyrrolidine-2,4-dione derivatives serving as pesticides | DDT, CYP4X1, PDHX | MAPK8 4118/4885TUBB4A 1531/4885TUBB 1268/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.