Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 17/20 | 0.61 |
| ▸ | PDE3A | Q14432 | 17/20 | 0.61 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.61 |
| ▸ | PDE4A | P27815 | 3/20 | 0.61 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.61 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.61 |
| ▸ | TDP2 | O95551 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20703085 | 0.88 | PDE3A (0.62) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL20703144 | 0.85 | PDE3B (0.69) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL20714742 | 0.85 | PDE3B (0.51) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL2846170 | 0.84 | PDE3B (0.77) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL20714430 | 0.82 | PDE3B (0.65) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL20703223 | 0.80 | PDE3B (0.58) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL20703149 | 0.79 | PDE3B (0.59) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL20714506 | 0.78 | PDE3B (0.68) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL20702770 | 0.78 | PDE3B (0.58) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL20702805 | 0.77 | PDE3B (0.64) | PDE3BPDE3APDE4BPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019025554-A1 | 6-PHENYL-4,5-DIHYDROPYRIDAZIN-3(2H)-ONE DERIVATIVES AS PDE3A AND PDE3B INHIBITORS FOR TREATING CANCER | BAYER AKTIENGESELLSCHAFT (DE) | 2019-02-07 | — | — | WO | disclosed |