Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EHMT2 | Q96KQ7 | 17/20 | 0.48 |
| ▸ | DNMT1 | P26358 | 11/20 | 0.48 |
| ▸ | NSD2 | O96028 | 3/20 | 0.44 |
| ▸ | ACP1 | P24666 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20720633 | 0.93 | EHMT2 (0.42) | EHMT2DNMT1NSD2ACP1 | |
| SCHEMBL20720687 | 0.92 | EHMT2 (0.43) | EHMT2DNMT1NSD2ACP1 | |
| SCHEMBL20720746 | 0.92 | EHMT2 (0.43) | EHMT2DNMT1NSD2ACP1 | |
| SCHEMBL20720607 | 0.92 | EHMT2 (0.43) | EHMT2DNMT1NSD2ACP1 | |
| SCHEMBL20720703 | 0.92 | EHMT2 (0.42) | EHMT2DNMT1NSD2ACP1 | |
| SCHEMBL20720609 | 0.89 | ACP1 (0.47) | EHMT2ACP1 | |
| SCHEMBL20720742 | 0.89 | ACP1 (0.45) | EHMT2DNMT1NSD2ACP1 | |
| SCHEMBL20720732 | 0.86 | EHMT2 (0.46) | EHMT2DNMT1 | |
| SCHEMBL20720632 | 0.84 | ACP1 (0.46) | EHMT2ACP1 | |
| SCHEMBL20720625 | 0.83 | ACP1 (0.45) | ACP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11254651-B2 | Histone methyltransferase inhibitors | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2022-02-22 | — | — | US | disclosed |
| EP-3416963-B1 | HISTONE METHYLTRANSFERASE INHIBITORS | GLOBAL BLOOD THERAPEUTICS INC (US) | 2021-07-28 | — | — | EP | disclosed |
| US-20190047981-A1 | HISTONE METHYLTRANSFERASE INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. | 2019-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190047981-A1 | HISTONE METHYLTRANSFERASE INHIBITORS | EHMT1, EHMT2, BMI1 | EHMT2 2/4885DNMT1 32/4885NSD2 127/4885 |
| US-11254651-B2 | Histone methyltransferase inhibitors | EHMT1, EHMT2, BMI1 | EHMT2 2/4885DNMT1 32/4885NSD2 127/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.