Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.46 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.41 |
| ▸ | EHMT2 | Q96KQ7 | 6/20 | 0.40 |
| ▸ | EHMT1 | Q9H9B1 | 5/20 | 0.40 |
| ▸ | ACP1 | P24666 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20720718 | 1.00 | CACNA2D1 (0.46) | CACNA2D1HTR4EHMT2EHMT1ACP1 | |
| SCHEMBL20720655 | 0.88 | FLT3 (0.42) | MET | |
| SCHEMBL20720729 | 0.85 | EHMT2 (0.52) | EHMT2EHMT1ADRA1A | |
| SCHEMBL20720657 | 0.85 | CACNA2D1 (0.44) | CACNA2D1HTR4EHMT2EHMT1ACP1 | |
| SCHEMBL20720716 | 0.85 | EHMT2 (0.50) | EHMT2EHMT1 | |
| SCHEMBL20720682 | 0.84 | EHMT2 (0.43) | HTR4EHMT2 | |
| Trifluoroacetic Acid SCHEMBL20720721 | 0.83 | CACNA2D1 (0.52) | CACNA2D1EHMT2EHMT1TLR9TLR7 | |
| Trifluoroacetic Acid SCHEMBL19260683 | 0.83 | CACNA2D1 (0.52) | CACNA2D1EHMT2EHMT1TLR9TLR7 | |
| Trifluoroacetic Acid SCHEMBL19260639 | 0.83 | CACNA2D1 (0.52) | CACNA2D1EHMT2EHMT1TLR9TLR7 | |
| SCHEMBL20720618 | 0.81 | EHMT2 (0.38) | HTR4EHMT2EHMT1HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11254651-B2 | Histone methyltransferase inhibitors | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2022-02-22 | — | — | US | disclosed |
| EP-3416963-B1 | HISTONE METHYLTRANSFERASE INHIBITORS | GLOBAL BLOOD THERAPEUTICS INC (US) | 2021-07-28 | — | — | EP | disclosed |
| US-20190047981-A1 | HISTONE METHYLTRANSFERASE INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. | 2019-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190047981-A1 | HISTONE METHYLTRANSFERASE INHIBITORS | EHMT1, EHMT2, BMI1 | CACNA2D1 1539/4885HTR4 3486/4885EHMT2 2/4885 |
| US-11254651-B2 | Histone methyltransferase inhibitors | EHMT1, EHMT2, BMI1 | CACNA2D1 1539/4885HTR4 3486/4885EHMT2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.