Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | CTH | P32929 | 1/20 | 0.35 |
| ▸ | CBS | P35520 | 1/20 | 0.35 |
| ▸ | THPO | P40225 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27720860 | 0.93 | CYP2C19 (0.40) | TSHRCTHCBSTHPOTHRB | |
| SCHEMBL18074854 | 0.74 | TSHR (0.33) | TSHRCTHCBSTHPOTHRB | |
| SCHEMBL20722072 | 0.71 | KDM4E (0.30) | TSHRALDH1A1 | |
| SCHEMBL31213026 | 0.70 | CYP1A2 (0.38) | TSHRCTHCBSTHPOTHRB | |
| SCHEMBL31213025 | 0.68 | CYP1A2 (0.41) | TSHRCTHCBSTHPOTHRB | |
| SCHEMBL22228986 | 0.67 | — | — | |
| SCHEMBL7175558 | 0.67 | CYP2C19 (0.33) | TSHRCTHCBSTHPOTHRB | |
| SCHEMBL29387013 | 0.65 | TSHR (0.42) | TSHRCTHCBSTHPOTHRB | |
| SCHEMBL5516435 | 0.65 | — | — | |
| SCHEMBL1734944 | 0.64 | PTGDR (0.33) | TSHRCTHCBSTHPOTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3665156-A1 | COMPOUNDS, COMPOSITIONS AND METHODS | Denali Therapeutics Inc. (US) | 2020-06-17 | — | — | EP | disclosed |
| WO-2019032743-A1 | COMPOUNDS, COMPOSITIONS AND METHODS | DENALI THERAPEUTICS INC. (US) | 2019-02-14 | — | — | WO | disclosed |