Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | KCNQ2 | O43526 | 8/20 | 0.50 |
| ▸ | KCNQ3 | O43525 | 6/20 | 0.50 |
| ▸ | KCNQ4 | P56696 | 3/20 | 0.47 |
| ▸ | KCNQ5 | Q9NR82 | 3/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2070063 | 0.89 | KMT2A (0.49) | CYP1A2CYP2C9CYP2C19SMN1; SMN2KCNQ2 | |
| SCHEMBL17665517 | 0.87 | HPGD (0.47) | CYP1A2CYP2C9CYP2C19SMN1; SMN2HDAC3 | |
| SCHEMBL6333634 | 0.83 | CYP1A2 (0.54) | CYP1A2CYP2C9CYP2C19SMN1; SMN2KCNQ2 | |
| SCHEMBL17653871 | 0.82 | NPC1 (0.51) | SMN1; SMN2HDAC3HDAC1HDAC2KMT2A | |
| SCHEMBL2069644 | 0.81 | SMN1; SMN2 (0.73) | CYP1A2CYP2C9CYP2C19SMN1; SMN2KCNQ2 | |
| SCHEMBL11451154 | 0.81 | CYP1A2 (0.61) | CYP1A2CYP2C9CYP2C19SMN1; SMN2KCNQ2 | |
| SCHEMBL4957900 | 0.81 | POLB (0.48) | CYP1A2CYP2C9CYP2C19SMN1; SMN2CYP2D6 | |
| SCHEMBL656064 | 0.80 | CYP1A2 (0.59) | CYP1A2CYP2C9CYP2C19SMN1; SMN2KCNQ2 | |
| SCHEMBL2072406 | 0.80 | CYP1A2 (0.59) | CYP1A2CYP2C9CYP2C19SMN1; SMN2KCNQ2 | |
| SCHEMBL21059165 | 0.80 | KMT2A (0.59) | CYP1A2CYP2C9CYP2C19CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7906537-B2 | Substituted p-diaminobenzene derivatives | H. LUNDBECK A/S (DK) | 2011-03-15 | — | — | US | disclosed |
| US-20060183791-A1 | Substituted p-diaminobenzene derivatives | H. LUNDBECK A/S (DK) | 2006-08-17 | — | — | US | disclosed |
| EP-1613303-A1 | SUBSTITUTED P-DIAMINOBENZENE DERIVATIVES | H. Lundbeck A/S (DK) | 2006-01-11 | — | — | EP | disclosed |
| WO-2004082677-A1 | SUBSTITUTED P-DIAMINOBENZENE DERIVATIVES | H. LUNDBECK A/S (DK) | 2004-09-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060183791-A1 | Substituted p-diaminobenzene derivatives | ABCB1, UGT2B7, CYP2D6 | CYP1A2 20/4885CYP2C9 25/4885CYP2C19 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.