Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.63 |
| ▸ | PIK3CD | O00329 | 14/20 | 0.63 |
| ▸ | MTOR | P42345 | 5/20 | 0.53 |
| ▸ | PIK3R1 | P27986 | 4/20 | 0.53 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.53 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.53 |
| ▸ | JAK2 | O60674 | 1/20 | 0.53 |
| ▸ | JAK1 | P23458 | 1/20 | 0.53 |
| ▸ | JAK3 | P52333 | 1/20 | 0.53 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.50 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16639089 | 0.87 | PIK3CA (0.63) | PIK3CAPIK3CDMTORPIK3R1PIK3CB | |
| SCHEMBL16639087 | 0.79 | PIK3CD (0.77) | PIK3CAPIK3CD | |
| SCHEMBL16639103 | 0.78 | PIK3CA (0.64) | PIK3CAPIK3CDMTORPIK3R1PIK3CB | |
| SCHEMBL10327870 | 0.78 | PIK3CA (0.68) | PIK3CAPIK3CDMTORPIK3R1PIK3CB | |
| SCHEMBL16639114 | 0.78 | PIK3CD (1.00) | PIK3CAPIK3CD | |
| SCHEMBL17053390 | 0.76 | PIK3CD (0.52) | PIK3CAPIK3CDMTORPIK3R1PIK3CB | |
| SCHEMBL16639140 | 0.75 | PIK3CD (1.00) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL20725682 | 0.75 | PIK3CD (0.88) | PIK3CAPIK3CD | |
| SCHEMBL20725691 | 0.74 | PIK3CD (0.89) | PIK3CAPIK3CD | |
| SCHEMBL16639083 | 0.74 | PIK3CD (1.00) | PIK3CAPIK3CDMTORPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2860181-B1 | FUSED PYRIMIDINE COMPOUND, AND PREPARATION METHOD, INTERMEDIATE, COMPOSITION AND USES THEREOF | SHANGHAI YINGLI PHARM CO LTD (CN) | 2019-02-13 | — | — | EP | disclosed |