Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 16/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 6/20 | 0.52 |
| ▸ | ABL1 | P00519 | 2/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | PRKDC | P78527 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | BCR | P11274 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17807065 | 0.89 | PIK3CD (0.64) | PIK3CDPIK3CGPIK3CAPIK3CBABL1 | |
| SCHEMBL9884132 | 0.88 | PIK3CD (0.51) | PIK3CDPIK3CGPIK3CAPIK3CBABL1 | |
| SCHEMBL20725943 | 0.87 | PIK3CG (0.57) | PIK3CDPIK3CGPIK3CAPIK3CBABL1 | |
| SCHEMBL18708922 | 0.87 | PIK3CD (0.58) | PIK3CDPIK3CGPIK3CAPIK3CBABL1 | |
| SCHEMBL23287707 | 0.87 | PIK3CG (0.68) | PIK3CDPIK3CGPIK3CAPIK3CBABL1 | |
| SCHEMBL23287712 | 0.86 | PIK3CG (0.60) | PIK3CDPIK3CGPIK3CAPIK3CBABL1 | |
| SCHEMBL24338880 | 0.86 | PIK3CD (0.60) | PIK3CDPIK3CGPIK3CAPIK3CBABL1 | |
| SCHEMBL9884077 | 0.85 | PIK3CG (0.58) | PIK3CDPIK3CGPIK3CAPIK3CBABL1 | |
| SCHEMBL9884076 | 0.85 | PIK3CG (0.54) | PIK3CDPIK3CGPIK3CAPIK3CBABL1 | |
| SCHEMBL9884078 | 0.85 | PIK3CG (0.54) | PIK3CDPIK3CGPIK3CAPIK3CBABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3613743-B1 | PROCESSES FOR THE PREPARATION OF 1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE DERIVATIVES | INTELLIKINE LLC (US) | 2022-03-16 | — | — | EP | disclosed |
| EP-3811974-A1 | TREATMENT OF CANCERS USING PI3 KINASE ISOFORM MODULATORS | Infinity Pharmaceuticals, Inc. (US) | 2021-04-28 | — | — | EP | disclosed |
| EP-3613743-A1 | PROCESSES FOR THE PREPARATION OF 1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE DERIVATIVES | Intellikine, LLC (US) | 2020-02-26 | — | — | EP | disclosed |
| EP-2240452-B1 | 1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE DERIVATIVES AS PI3 KINASE MODULATORS, THEIR COMPOSITIONS AND USES | INTELLIKINE LLC (US) | 2019-05-29 | — | — | EP | disclosed |
| EP-3441392-A1 | A PHARMACEUTICAL COMPOSITION FOR ORAL ADMINISTRATION | Intellikine, LLC (US) | 2019-02-13 | — | — | EP | disclosed |