SCHEMBL20725941

SCHEMBL20725941

Cc1cccc2cc(Cn3nc(-c4ccccc4)c4c(N)ncnc43)n(C3CCCC3)c(=O)c12

nearest known ligand 0.61

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
PIK3CG P48736 8/20 0.61
PIK3CD O00329 18/20 0.59
PIK3CA P42336 6/20 0.53
PIK3CB P42338 6/20 0.53
PRKDC P78527 4/20 0.53
ABL1 P00519 1/20 0.53
SRC P12931 1/20 0.53
MTOR P42345 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9884118 0.92 PIK3CD (0.62) PIK3CGPIK3CDPIK3CAPIK3CBPRKDC
SCHEMBL9884178 0.91 PIK3CD (0.61) PIK3CGPIK3CDPIK3CAPIK3CBPRKDC
SCHEMBL9884181 0.91 PIK3CD (0.62) PIK3CGPIK3CDPIK3CAPIK3CBPRKDC
SCHEMBL18708721 0.90 PIK3CG (0.52) PIK3CGPIK3CDPIK3CAPIK3CBPRKDC
SCHEMBL18708930 0.89 PIK3CG (0.51) PIK3CGPIK3CDPIK3CAPIK3CBPRKDC
SCHEMBL9884170 0.89 PIK3CD (0.61) PIK3CGPIK3CDPIK3CAPIK3CBPRKDC
SCHEMBL18708994 0.88 PIK3CG (0.52) PIK3CGPIK3CDPIK3CAPIK3CBPRKDC
SCHEMBL9884126 0.88 PIK3CD (0.75) PIK3CGPIK3CDPIK3CAPIK3CBPRKDC
SCHEMBL9884134 0.88 PIK3CG (0.58) PIK3CGPIK3CDPIK3CAPIK3CBPRKDC
SCHEMBL9884127 0.88 PIK3CG (0.61) PIK3CGPIK3CDPIK3CAPIK3CBPRKDC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3441392-A1 A PHARMACEUTICAL COMPOSITION FOR ORAL ADMINISTRATION Intellikine, LLC (US) 2019-02-13 EP disclosed