Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHB3 | P54753 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 2/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.38 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23938061 | 0.81 | EPHB3 (0.46) | EPHB3HTR2CHTR2AHTR2BALDH1A1 | |
| SCHEMBL31383575 | 0.79 | EPHB3 (0.45) | EPHB3HTR2CHTR2AHTR2BALDH1A1 | |
| SCHEMBL26661950 | 0.78 | HTR2C (0.44) | EPHB3HTR2CHTR2AHTR2BMEN1 | |
| SCHEMBL24656136 | 0.77 | EPHB3 (0.43) | EPHB3HTR2CHTR2AHTR2BALDH1A1 | |
| SCHEMBL20731021 | 0.77 | SMPD3 (0.45) | EPHB3HTR2CHTR2ASMPD3ALDH1A1 | |
| SCHEMBL27432445 | 0.76 | EPHB3 (0.58) | EPHB3KDM4E | |
| SCHEMBL25290025 | 0.76 | TAAR1 (0.46) | EPHB3HTR2CHTR2AHTR2BMEN1 | |
| SCHEMBL3069691 | 0.76 | HTR2A (0.51) | EPHB3HTR2CHTR2AHTR2BALDH1A1 | |
| SCHEMBL15897953 | 0.74 | EPHB3 (0.59) | EPHB3ALDH1A1THRBKDM4ESMN1; SMN2 | |
| SCHEMBL3612887 | 0.73 | EPHB3 (0.61) | EPHB3ALDH1A1KMT2ACYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020033707-A1 | CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2020-02-13 | — | — | WO | disclosed |
| WO-2019032863-A1 | CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2019-02-14 | — | — | WO | disclosed |